{"created":"2025-08-19T00:44:49.283317+00:00","id":2000167,"links":{},"metadata":{"_buckets":{"deposit":"3e32a4db-84d1-45dc-9d19-210e88185682"},"_deposit":{"created_by":9,"id":"2000167","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000167"},"status":"published"},"_oai":{"id":"oai:auhw.repo.nii.ac.jp:02000167","sets":["279:1739434221120"]},"author_link":[],"control_number":"2000167","item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"21","bibliographicPageStart":"12","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"青森保健医療福祉研究","bibliographic_titleLang":"ja"},{"bibliographic_title":"Aomori Journal of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[目的]プラセンタエキスが更年期症状の改善に有効であるか否かを，システマティックレビュー及びメタアナリシスにより解析して検証した。\n[方法]プラセンタエキスをヒトに投与して，更年期症状の改善の有無を解析したランダム化比較試験を複数の電子データベース(医中誌，CiNii，PubMed，Cochrane library，及びEmbase)で検索した。選定基準を満たす論文を対象とし，論文の質をModified Jadad scaleで評価し，次いでEasy Rにより，更年期症状の改善及び更年期症状に関係するホルモンの分泌の変動に関するメタアナリシスを行った。\n[結果]最終的に9編の論文がメタアナリシスの対象となった。更年期症状の総合評価と易疲労性の評価から，プラセンタエキスは改善効果を示すことが明らかになった。また，プラセンタエキスはエストロゲンの分泌を促進しなかったが，卵胞刺激ホルモンの分泌は低下させた。\n[結論]プラセンタエキスは更年期症状の改善に一定の効果を示すことが確認された。エストロゲンの分泌を促進しないことから，プラセンタエキスは女性ホルモンのホルモン補充療法の代替療法ではなく，症状改善を目的とした補助療法の役割が期待されると考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"[Objective] This study aimed to verify whether placental extract is effective in proving menopausal symptoms through a systematic review and meta-analysis.\n[Methods] Randomized controlled trials that administered placental extract to humans and analyzed the improvement of menopausal symptoms were searched across multiple electronic databases (Ichushi, CiNii, PubMed, Cochrane Library, and Embase). Studies meeting The selection criteria were evaluated for quality using the Modified Jadad scale, followed by a meta-analysis regarding the improvement of menopausal symptoms and changes in the secretion of hormones related to those symptoms using Easy R.\n[Results] Nine studies were included in the meta-analysis. From the overall assessment of menopausal symptoms and the evaluation of fatigue, it was revealed that placental extract showed an improvement effect. Additionally, while placental extract did not promote the secretion of estrogen, it decreased the secretion of follicle-stimulating hormone.\n[Conclusion] It was confirmed that placental extract has a certain effect on improving menopausal symptoms. Since it does not promote the secretion of estrogen, it is considered that placental extract is not an alternative therapy for hormone replacement therapy with female hormones, but rather an adjunctive therapy aimed at symptom improvement.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"青森県立保健大学","subitem_publisher_language":"ja"}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"J-STAGE"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.60395/ajhw.7.1.12","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"item_10001_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"2435-6794","subitem_source_identifier_type":"EISSN"}]},"item_10001_textarea_25":{"attribute_name":"item_10001_textarea_25","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"J-STAGE公開日: 2025-03-18"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"浅水, 希","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"Asamizu, Nozomi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"髙橋, 実夢","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"Takahashi, Miyu","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"今, 淳","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"Kon, Atsushi","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"プラセンタエキス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"更年期症状","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"システマティックレビュー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メタアナリシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"placental extract","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"menopausal symptoms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"systematic review","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"meta-analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"プラセンタエキスの更年期症状に対する効果：システマティックレビュー及びメタアナリシスによる検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プラセンタエキスの更年期症状に対する効果：システマティックレビュー及びメタアナリシスによる検証","subitem_title_language":"ja"},{"subitem_title":"Effects of placental extract on menopausal symptoms : A systematic review and meta-analysis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["1739434221120"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-08-19"},"publish_date":"2025-08-19","publish_status":"0","recid":"2000167","relation_version_is_last":true,"title":["プラセンタエキスの更年期症状に対する効果：システマティックレビュー及びメタアナリシスによる検証"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-12-02T08:17:15.702126+00:00"}