{"created":"2023-06-19T09:22:10.954560+00:00","id":813,"links":{},"metadata":{"_buckets":{"deposit":"82281cf7-17bc-4e38-a63c-5b5b08a2796f"},"_deposit":{"created_by":4,"id":"813","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"813"},"status":"published"},"_oai":{"id":"oai:auhw.repo.nii.ac.jp:00000813","sets":["2:127"]},"author_link":[],"control_number":"813","item_6_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割"},{"subitem_alternative_title":"Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension ; 高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割"}]},"item_6_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-03-18"}]},"item_6_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"青森県立保健大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"21102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(健康科学)","subitem_degreename_language":"ja"}]},"item_6_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_23":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"List of Tables\nList of Figures\nAbstract\nChapter 1. General Introduction\nChapter 2. Supression of vascular and renal oxidative stress\n2.1 Effect of azuki bean seed coats (ABSC) on superoxide production in\nspontaneously hypertensive rats\n2.2 Effect of azuki bean extract (ABE) on nitric oxide metabolism in\nspontaneously hypertensive rats\n2.3 Discussion\nChapter 3. Supression of vascular inflammation\n3.1 Effect of azuki bean seed coats (ABSC) on vascular inflammation in\nspontaneously hypertensive rats\n3.2 Discussion\nChapter 4. General Discussion\nChapter 5. Conclusion\nAcknowledgements\nReferences","subitem_description_language":"en","subitem_description_type":"TableOfContents"}]},"item_6_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of the present study was to examine whether azuki bean polyphenols would contribute to attenuation of hypertension, if so, to clarify the physiological role in oxidative stress and inflammation with hypertension.\nMale spontaneously hypertensive rats/Izumo (SHR) and control normotensive WKY/Izumo (WKY) rats were randomly divided into 2 groups each, treated or untreated with polyphenols-containing azuki bean seed coats (ABSC) or extract (ABE). When the systolic blood pressure of SHR reached approximately 200 mmHg, they were administered each diet for 8 weeks. The blood pressure and heart rate were measured once every 2 weeks by the tail-cuff plethysmography method. The nitric oxide (NO) content in 24-h urine was measured by Griess method. After sacrifice, superoxide (O2) production in aorta was determined using a lucigenin-enhanced chemiluminescence technique. Vascular mRNA levels of NADPH oxidase subunits, Nox4, p47phox and p22phox, and monocyte chemoattractant protein 1 (MCP-1) and its receptor CCR2 were respectively analyzed by real-time RT-PCR. Vascular or renal protein levels of superoxide dismutase (SOD), endothelial NO synthase (eNOS), cavelin-1, inducible NOS (iNOS) and cyclooxygenase 2 (COX-2) were respectively analyzed by western blotting.\nAzuki bean polyphenols such as procyanidin and catechin, contained in ABSC and ABE, reduced the elevated blood pressure in long-term treatment of SHR. ABSC treatment decreased the vascular production of O2, and suppressed the mRNA expression of the p47phox subunit of NADPH oxidase in the aorta. ABE treatment increased the renal Cu/Zn-SOD expressions. ABE treatment increased the urinary NOx content, indicating an increased NO production. ABE treatment modulated the eNOS and caveolin-1 expressions in the aorta and kidney of SHR. ABSC treatment suppressed the mRNA expressions of MCP-1, its receptor CCR2, and the protein expression of MCP-1. ABSC treatment suppressed the protein expressions of iNOS and COX-2 in the aorta of SHR. In conclusion, azuki bean polyphenols were showed to contribute to attenuation of oxidative stress and inflammation with hypertension. These effects may lead to prevention of NO inactivation and immune cells infiltration, associated with amelioration of endothelial dysfunction.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第10号"}]},"item_6_heading_22":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"青森県立保健大学大学院博士論文. 2009年度","subitem_heading_language":"ja"}]},"item_6_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24552/00000807","subitem_identifier_reg_type":"JaLC"}]},"item_6_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"向井, 友花","creatorNameLang":"ja"},{"creatorName":"ムカイ, ユウカ","creatorNameLang":"ja-Kana"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-08"}],"displaytype":"detail","filename":"0793002.pdf","filesize":[{"value":"693.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"0793002.pdf","url":"https://auhw.repo.nii.ac.jp/record/813/files/0793002.pdf"},"version_id":"273201f1-fd86-431f-83d9-3b15bd524f09"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_thumbnail":{"attribute_name":"サムネイル","attribute_value_mlt":[{"subitem_thumbnail":[{"thumbnail_label":"0793002.png","thumbnail_url":"/api/files/34497019-3407-4887-b939-4a2d8e9e8906/0793002.png?versionId=66e7d64b-dda4-4693-99c4-ae7c93348885"}]}]},"item_title":"Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension","subitem_title_language":"en"}]},"item_type_id":"6","owner":"4","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-02-24"},"publish_date":"2011-02-24","publish_status":"0","recid":"813","relation_version_is_last":true,"title":["Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-12-08T02:52:28.806833+00:00"}